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$20 Million Gift Boosts Multiple Myeloma Research
Siteman Cancer Center
Scottrade brokerage founder Rodger Riney and his wife, Paula, have donated $20 million to Washington University researchers at Siteman Cancer Center, establishing the Pau…
$11.5 Million SPORE Grant Supports Innovation in Leukemia Research
Siteman Cancer Center
Washington University researchers at Siteman Cancer Center have received an $11.5 million Specialized Program in Research Excellence (SPORE) grant to further high-level i…
Duke Team Receives $10.8 Million From NCI
Duke Cancer Institute, Duke University Medical Center
The National Cancer Institute awarded $10.8 million to Duke Cancer Institute researchers as part of the Human Tumor Atlas Network, which w…
Johnson Named Among Women Power 100
Roswell Park Comprehensive Cancer Center
Roswell Park's president and CEO, Candace S. Johnson, PhD, has been named to a new list of the most powerful female leaders in New York. City & State, a m…
Grant Awarded to Discover Best Way to Deliver Genetic Services to Primary Care Patients
Huntsman Cancer Institute at the University of Utah
An interdisciplinary team of researchers at Huntsman Cancer Institute at the University of Utah was recently awarded a prestigious team scie…
CAR T Clinical Trial Opens for Patients with HER2-Positive Breast Cancer That Has Spread to Brain
City of Hope Comprehensive Cancer Center
Women with HER2-positive breast cancer that has spread to the brain need more treatment options, and City of Hope and Mustang Bio Inc. are meeting tha…
Grant to Establish Center for Early Detection of Liver Cancer
UCLA Jonsson Comprehensive Cancer Center
Researchers from the UCLA Jonsson Comprehensive Cancer Center received a $3.5 million, five-year grant from the NIH to create a center dedicated to dev…
$2.3 Million Supports Studies on Chemotherapy-Induced Peripheral Neuropathy
Indiana University Melvin and Bren Simon Comprehensive Cancer Center
Jill Fehrenbacher, PhD, and Mark Kelley, PhD, are recipients of a five-year grant from the National Cancer Institute, which…
Anti-CD47 Cancer Therapy Safe, Shows Promise in Small Clinical Trial
Stanford Cancer Institute
A novel immunotherapy appears safe for use in patients with non-Hodgkin’s lymphoma, according to a Phase I multicenter clinical trial led by a researcher at the Stanf…
$2.1 Million Grant to Study Cognitive Decline During Chemotherapy
VCU Massey Comprehensive Cancer Center
With the help of a $2.1 million grant, Virginia Commonwealth University Massey Cancer Center and VCU School of Nursing researchers will study how a gene …
Developing Patient-Centered Palliative Care From Diagnosis to End of Life
Livestrong Cancer Institutes, The University of Texas at Austin, Dell Medical School
In December, The University of Texas at Austin Dell Medical School will launch an innovative cancer care mo…
New Way That Skin Stops Tumor Growth Identified
Fred Hutchinson Cancer Center
In newly published work, Hutch researchers show that skin stem cells in mice respond to what ought to have been a cancer-causing mutation by opting to differentia…
Decrease in Specific Gene ‘Silencing’ Molecules Linked with Pediatric Brain Tumors
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University
Experimenting with lab-grown brain cancer cells, Johns Hopkins Medicine researchers have added to evidence that a shortage…
Husband and Wife Doctors Receive $1.8 Million to Test New Breast Cancer Approach
University of Virginia Cancer Center
The NIH has awarded a husband-and-wife team at UVA Cancer Center more than $1.8 million to improve radiation therapy and breast surgery for patients with e…
Standard Myeloma Treatment Shows Itself as an Immunotherapy
Fred Hutchinson Cancer Center
New research suggests that doctors may have had an incorrect understanding of how a standard treatment for an incurable blood cancer works to prolong lives. The t…
When Melanoma Spreads to Brain, Patients with BRAF, MEK Mutations Can Find Novel Treatment
The University of Arizona Cancer Center
In partnership with Spirita Oncology, LLC, Hani Babiker, MD, and the Early Phase Clinical Trials Program have opened a clinical trial for patients with …
Minimally-Invasive Surgery Linked with Worse Survival for Women with Cervical Cancer Versus Open Hysterectomy
The University of Texas MD Anderson Cancer Center
When comparing standard-of-care surgical options for women with early-stage cervical cancer, two studies led by researchers at The University …
Polish University Partnership
Roswell Park Comprehensive Cancer Center
Roswell Park has formed an academic cooperation agreement with the Jagiellonian University in Kraków, Poland. The collaboration will see the two center…
Targeting Rhabdomyosarcoma, a Rare Cancer with Few Treatment Options
The University of Arizona Cancer Center
The most comprehensive assessment of rhabdomyosarcoma drug targets was published. Justina McEvoy, PhD, a first author, joined the study when she was a p…
Rural Residents at Much Higher Larynx Cancer Risk
Fox Chase Cancer Center, Temple Health
According to a new study, individuals living in rural areas are at greater risk of developing laryngeal cancer compared to those living in urban areas, t…
Spread of Deadly Eye Cancer Halted in Cells, Animals
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University
By comparing genetic sequences in the eye tumors of children whose cancers spread with tumors that didn’t, Johns Hopkins M…
Cold Therapy Offers Promising Prevention Against Taxane-Induced Dermatologic Events
GW Cancer Center
Researchers at the George Washington University (GW) have found that cooling therapies such as cold caps, scalp cooling systems, frozen gloves, and frozen socks may offer the …
Omuro Named New Neuro-Oncology Chief
Yale Cancer Center, Yale School of Medicine
Antonio Omuro, MD, has been appointed the new chief of neuro-oncology and a leader for the Brain Tumor Program at Smilow Cancer Hospital. Dr. Omuro …
Unique Research Models Immune Responses in Cellular Immunotherapies
VCU Massey Comprehensive Cancer Center
In the Cellular Immunotherapy and Transplantation Program at Virginia Commonwealth University Massey Cancer Center, scientists are pursuing a cross-colla…
Link Identified Between DNA-Protein Binding, Cancer Onset
Stanford Cancer Institute
Researchers at the Stanford University School of Medicine and their collaborators at other institutions have identified a link between how proteins bind to our DNA an…
Fecal Transplant Effective Against Immunotherapy-Induced Colitis
The University of Texas MD Anderson Cancer Center
For the first time, gut bacteria transplanted from healthy donors was used to successfully treat patients suffering from colitis caused by imm…
As Vaping Increased in Popularity, Use of Cigarettes Declined
Georgetown Lombardi Comprehensive Cancer Center
A comprehensive analysis examining the relationship between vaping and smoking among youth and young adults finds that cigarette smoking dramati…
Whetstine Joins Cancer Epigenetics Program
Fox Chase Cancer Center, Temple Health
Epigenetics researcher Johnathan Whetstine, PhD, joined Fox Chase as program leader of the Cancer Epigenetics Program. Previously, Dr. Whetstine served a…
Pediatrician is Inaugural Pagano Scholar
Indiana University Melvin and Bren Simon Comprehensive Cancer Center
A leading pediatrician will be the inaugural Chuck and Tina Pagano Scholar at Indiana University School of Medicine. Rachel Katzen…
Ultrasound Ovarian Cancer Screening Improves Survival
UK Markey Cancer Center
A new University of Kentucky study shows that annual ultrasound screening of at-risk, asymptomatic women increases the survival rates of women with type I and type II e…
Targeting MC1R in Metastatic Melanoma
University of Colorado Cancer Center
A University of Colorado Cancer Center study describes a genetic change common to 80 percent of human melanomas, the most deadly form of skin cancer, and a…
New ‘SLICE’ Tool Can Massively Expand Immune System’s Cancer-Fighting Repertoire
UCSF Helen Diller Family Comprehensive Cancer Center
UC San Francisco researchers have devised a CRISPR-based system called SLICE, which will allow scientists to rapidly assess the function of…
How Melanoma Evades Targeted Therapies
Sidney Kimmel Cancer Center at Jefferson Health
A commonly used targeted therapy for metastatic melanomas works by attacking melanomas with mutations in the BRAF gene that make them susceptibl…
A Genetic Driver of Deadly Prostate Cancer Identified
Cedars-Sinai Cancer
A new study has identified a novel molecular driver of lethal prostate cancer, along with a molecule that could be used to attack it. The findings were made in laboratory m…
St. Clair Receives Lifetime Achievement Award
UK Markey Cancer Center
University of Kentucky Markey Cancer Center researcher Daret St. Clair, PhD, has been named the 2018 Lifetime Achievement Award Recipient from the Society for Redox Biology an…
Lu-Yao Awarded by Geriatric Oncology Society
Sidney Kimmel Cancer Center at Jefferson Health
Grace Lu-Yao, PhD, associate director of population science at the Sidney Kimmel Cancer Center – Jefferson Health, has been honored with the Internatio…
Lisenbee Elected to APSHO Board
Duke Cancer Institute, Duke University Medical Center
Kelly Lisenbee, DNP, ANP-C, AOCN, adult nurse practitioner, Department of Urologic Surgery, was recently elected to the board of directors for th…
Will Tarloxotinib Finally Break the HER2 Barrier in Lung Cancer?
University of Colorado Cancer Center
A University of Colorado Cancer Center study shows the promise of an innovative new strategy against HER2-driven lung cancers (with EGFR involvement, which…
Researchers ID‘Achilles Heel’ of Drug-Resistant Tumors
UCSF Helen Diller Family Comprehensive Cancer Center
UC San Francisco scientists have figured out why some lung cancers become drug-resistant after initially responding to targeted therapies. …
McMahon Receives Pancreatic Cancer Collective Grant
Huntsman Cancer Institute at the University of Utah
Martin McMahon, PhD, has received a grant from the Pancreatic Cancer Collective, the strategic partnership of the Lustgarten Foundation and …
Human Images From the World’s First Total-Body Medical Scanner Unveiled
UC Davis Comprehensive Cancer Center
EXPLORER, the world’s first medical imaging scanner that can capture a 3-D picture of the whole human body at once, has produced its first scans. The brain…
Stephenson Cancer Center Leads Ovarian Cancer Study
Stephenson Cancer Center, University of Oklahoma
Kathleen Moore, MD, a physician-scientist at Stephenson Cancer Center at OU Medicine, co-directed an international clinical trial that yielded …
New Checkpoint Inhibitor Shows Promise in Non-Hodgkin Lymphoma Trial
The University of Chicago Medicine Comprehensive Cancer Center
By combining the experimental anti-cancer antibody known as 5F9 (Hu5F9-G4) with the established anti-cancer antibody rituximab, r…
Dlugosz to Oversee Basic Science Research
University of Michigan Rogel Cancer Center
The University of Michigan Rogel Cancer Center has named Andrzej Dlugosz, MD, associate director for basic science research. Dr. Dlugosz currently co…
December 2018
Winter Break for AACI Update
Please let us know what you think about the new format of the December 2018 AACI Update!
AACI Update will take a holiday break in January, but we will be working to improve the February 1, 2019 issu…
Webinar: Minority Recruitment to Clinical Trials
The AACI Physician Clinical Leadership Initiative (PCLI) will present a webinar on minority recruitment to clinical trials on Thursday, December 13 at 12:00 pm eastern. Facilitated by Ruben A. Mesa, …
Nominations Sought for Champion for Cures Award
Nominations are now being accepted for the 2019 Champion for Cures Award.AACI created the Champion for Cures Award to recognize an individual or individuals who, through direct financial support of…
New Congress Brings New Opportunities
The 116th Congress will convene on January 3, 2019 with nine new members of the United States Senate and 92 new members of the House of Representatives. The incoming Congress is the most demographica…
eRegulatory Working Group Established
While most AACI cancer centers have in place a regulatory file system—either paper or an electronic system for the filing and version control of a trial’s required regulatory information—many utilize…
CRI: From ‘Initiative’ to ‘Innovation’
Entering its eleventh year, AACI's Clinical Research Initiative (CRI) has been renamed Clinical Research Innovation, to mark its popularity and success. Earlier this year, AACI sought recommendations…
AACI Debuts New Website
AACI recently launched a redesigned website, which will serve as a powerful tool to support communication between AACI and our 98 cancer center members.The responsive, mobile-friendly interface of…
Genomic Study Discovers 40 New Genetic Variants Associated with Colorectal Cancer
Fred Hutchinson Cancer Center
The most comprehensive genome-wide association study, or GWAS, of colorectal cancer risk to date, has discovered 40 new genetic variants and validated 55 previous…
Improved Understanding of Renal Cell Cancer Mutations, Identification of Biomarkers May Inform Future Treatment
Fox Chase Cancer Center, Temple Health
While renal cell cancer treatments have improved as researchers gained a deeper understanding of the disease’s genetics and genomics, there is an opportu…
John Mendelsohn, MD Anderson President Emeritus, Passes Away
The University of Texas MD Anderson Cancer Center
John Mendelsohn, MD, president emeritus of The University of Texas MD Anderson Cancer Center and an internationally acclaimed scientist whose …
Pelotonia 2018 Generates More Than $27 Million for Cancer Research
The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute
Pelotonia riders and volunteers raised a record-breaking $27.4 million through the 2…
Researchers Aim to Develop Radiation Therapy with Short Exposure Times
Stanford Cancer Institute
New accelerator-based technology being developed by the Department of Energy’s SLAC National Accelerator Laboratory and Stanford University aims to reduce the side ef…
Advanced Drug Delivery System with Highest Tumor-Targeting Ability Developed
VCU Massey Comprehensive Cancer Center
In pre-clinical studies, VCU Massey Cancer Center scientists, led by Hu Yang, PhD, have developed a novel drug delivery system using nanoparticles that s…
Brawley to Direct Outreach, Disparities Research
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University
Otis W. Brawley, MD, former chief medical and scientific officer for the American Cancer Society, has been named a Bloomb…
$26 Million ‘Grand Challenge’ Project Will Probe Role of Inflammation in Cancer
UCSF Helen Diller Family Comprehensive Cancer Center
UC San Francisco Professor Thea Tlsty, PhD, is a winner of the “Grand Challenge” competition sponsored by Cancer Research UK, an ambitious …
Gerson Tapped for Biden Cancer Working Group
Case Comprehensive Cancer Center
AACI Immediate Past President Stanton L. Gerson, MD, director, Case Comprehensive Cancer Center, has been named to the Biden Cancer Initiative Data Sharing Working Gr…
Personalized Medicine Tool Developed for Inherited Colorectal Cancer Syndrome Risk
Huntsman Cancer Institute at the University of Utah
An international team of researchers led by Huntsman Cancer Institute at the University of Utah has developed, calibrated, and validated a n…
Improved Survival Shown in Pediatric Hodgkin Lymphoma Patients When Receiving Combined Modality Treatment
Rutgers Cancer Institute of New Jersey
Research from Rutgers Cancer Institute of New Jersey shows improved overall survival at five years for pediatric patients with early-stage Hodgkin lympho…
HPV Discovery Raises Hope for New Cervical Cancer Treatments
University of Virginia Cancer Center
Researchers at the University of Virginia School of Medicine have made a discovery about human papillomavirus (HPV) that could lead to new treatments for c…
Weiner Named a National Academy of Inventors Fellow
Georgetown Lombardi Comprehensive Cancer Center
The National Academy of Inventors (NAI) has named Louis M. Weiner, MD, director of Georgetown Lombardi Comprehensive Cancer Center, to its 2018 class o…
Tumor Microenvironment Targeted to Shut Down Liver Cancer
VCU Massey Comprehensive Cancer Center
For nearly a decade, VCU Massey Cancer Center researcher Devanand Sarkar, PhD, has uncovered new insights into the development and progression of liver c…
Grant to Support Study of E‑Cigs, Oral Health
The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute
Researchers at the OSUCCC - James, led by Purnima Kumar, DDS, PhD, have landed a fiv…
Neurosurgeon-scientist Honored for Work in Lab, Clinic
UCLA Jonsson Comprehensive Cancer Center
Linda Liau, MD, PhD, MBA, has been awarded the Abhijit Guha Award for her pioneering work on treating brain tumors. Established in memory of the late Dr. Abhi…
Engineered Immune Cells Target Pediatric Solid Tumors in Mice
Stanford Cancer Institute
Immune cells engineered to attack childhood cancers were able to eradicate different types of pediatric tumors in mice, according to a new study from the Stanford Uni…
NCI-Funded Study Aims to Enhance Glioblastoma Treatment
Cleveland Clinic Cancer Center
Jeongwu Lee, PhD, was awarded a five-year, $2.4 million grant from the National Cancer Institute, part of the National Institutes of Health, to study an FDA-appr…
Soper Inducted into AIMBE College of Fellows
The University of Kansas Cancer Center
Steven Soper, PhD, was elected to the American Institute for Medical and Biomedical Engineering (AIMBE) College of Fellows. The AIMBE College of Fellows represe…
Exciting Early Results in Trial of Immunotherapy for Myeloma
Fred Hutchinson Cancer Center
Eleven patients had already received numerous treatments for their cancers, some as many as 20 different courses of therapy. Yet their myelomas, almost all classi…
Cancer Drugs Speed Repair in Lungs Damaged by Bacterial Infections
Duke Cancer Institute, Duke University Medical Center
Cancer drugs are able to halt life-threatening bacterial lung infections in mouse models by promoting lung repair, researchers at Duke Hea…
Geneticist Joins UMMC Cancer Institute
UMMC Cancer Center and Research Institute
Yann Gibert, PhD, has joined the University of Mississippi Medical Center Cancer Institute as an associate professor in the CI Cancer Molecular Biolog…
Researchers Investigate Nanoimmunotherapies for Cancer
GW Cancer Center
A GW Cancer Center team has engineered a nanoimmunotherapy combining the advantages of nanotechnology and immunotherapy to treat cancer. The goal of this combination is to inc…
Puzanov Honored for Melanoma Research
Roswell Park Comprehensive Cancer Center
Igor Puzanov, MD, MSci, FACP, was honored for his “outstanding and lifelong contributions to melanoma research” during the just-concluded Melanoma and Immunot…
Sprayable Gel Could Help Body Combat Cancer After Surgery
UCLA Jonsson Comprehensive Cancer Center
Many people who are diagnosed with cancer will undergo some type of surgery to treat their disease. But despite improvements in surgical techniques ove…
Complication Rates, Costs of Invasive Lung Cancer Diagnostic Tests May Be Higher Than Expected
The University of Texas MD Anderson Cancer Center
Complication rates following invasive diagnostic procedures for lung abnormalities were twice as high in the community setting compared to tho…
Christmas Berry Plant Could Fight Uveal Melanoma
Sidney Kimmel Cancer Center at Jefferson Health
Researchers at the Sidney Kimmel Cancer Center at Jefferson Health and the Icahn School of Medicine at Mt. Sinai have found that a compound extr…
Grant Helps Unravel Role of Glucose, Fats in Bone Cancer
Indiana University Melvin and Bren Simon Comprehensive Cancer Center
A $1.2 million Department of Defense grant has been awarded to Theresa Guise, MD, whose research explores a cascade of even…
New Algorithm Improves Online Survey Data Reliability
Fox Chase Cancer Center, Temple Health
Elizabeth Handorf, PhD, has developed a new method that makes analysis of data collected online more reliable by eliminating repeat responders. Her metho…
Patel to Lead Multidisciplinary Cutaneous Oncology Program
GW Cancer Center
The George Washington University (GW) Cancer Center has announced that Vishal A. Patel, MD, FAAD, FADMC, has joined the cancer center. He will serve as the director of the re…
Ruckdeschel Named to Lung Roundtable
UMMC Cancer Center and Research Institute
John Ruckdeschel, MD, University of Mississippi Medical Center Cancer Institute director, has been named to the National Lung Cancer Roundtable. Established …
Khabele Elected as ASCI Member
The University of Kansas Cancer Center
Dineo Khabele, MD, director of The University of Kansas Cancer Center’s gynecologic oncology division, has been elected a new member to the American Society for…
$30 Million Gift Will Transform University of Alabama Cancer Center
O’Neal Industries, Inc., a family-owned global business based in Birmingham, and its shareholders have given the largest single gift in the University of Alabama at Birmingham’s history—a $30 million…
Study Unveils 40 New Mutations Linked to Colorectal Cancer
Fred Hutchinson Cancer Center
A group of colorectal cancer researchers are using the word “milestone” to describe their new genomic research. The product of more than five years’ work by scien…
Meyerson Named Chief of Thoracic Surgery
UK Markey Cancer Center
Thoracic surgeon and educator Shari Meyerson, MD, MEd, has joined UK HealthCare as the new chief of thoracic surgery. Meyerson will direct the section of thoracic surge…
Medical Director Named for Center for Brain and Spine Metastasis
Duke Cancer Institute, Duke University Medical Center
Medical oncologist Carey Anders, MD, has been appointed medical director for the DCI Center for Brain and Spine Metastasis and has joined …
Hazlehurst Named Associate Director
WVU Cancer Institute
Lori Hazlehurst, PhD, has been named as the associate director for basic research at the WVU Cancer Institute. In this role, she will work closely with the leadership team…
Artificial Intelligence Officer Hired
Moffitt Cancer Center
J. Ross Mitchell, PhD, has joined Moffitt Cancer Center as the artificial intelligence officer. The new role will lead the development of digital tools that utilize compu…
Opioid Prescriptions Can Be Drastically Reduced After Surgery with No Increase in Pain
Roswell Park Comprehensive Cancer Center
A two-year study by a multidisciplinary team of surgeons and other cancer specialists found that the amount of opioid medications prescribed after surg…
Join Us for the 2019AACI/AACR Hill Day
AACI and the American Association for Cancer Research (AACR) will co-host the 2019 Hill Day in Washington, DC, on Tuesday, April 30. AACI is encouraging its U.S. members to send at least one represen…
Chen Honored with Chair in Oncology
Winship Cancer Institute of Emory University
Jing Chen, PhD, professor and director of the Division of Basic & Translational Science in the Department of Hematology and Medical Oncology in the Em…
CAR T Listserv Now Open to AACI Members
AACI has launched a CAR T listserv to allow for greater engagement among members who want to share best practices, challenges, and solutions related to CAR T-cell therapy implementation. The listserv…
Osley Appointed to NCI Board for Basic Sciences
University of New Mexico Comprehensive Cancer CenterMary Ann Osley, PhD, has been appointed to a four-year term on the NCI Board of Scientific Counselors for Basic Sciences, which advises on scient…
AACI Welcomes ASTRO as New Sustaining Member
AACI kicked off 2019 by welcoming a new sustaining member. The American Society for Radiation Oncology (ASTRO) is the premier radiation oncology society in the world. ASTRO’s membership is comprised …
Targeting an ‘Energy Crisis’ in the Treatment of Non-Small Cell Lung Cancer
Rutgers Cancer Institute of New Jersey
When it comes to stopping a common form of lung cancer, an energy crisis is a good thing. Research from investigators at Rutgers Cancer Institute of New …
New Insights Regarding Genetic Contribution to Inherited Prostate Cancer
Sidney Kimmel Cancer Center at Jefferson Health
Newly published research from Sidney Kimmel Cancer Center at Jefferson Health investigators provides a snapshot of the spectrum of genetic chang…
Call for Abstracts for the 11th Annual AACICRI Meeting
The AACI Clinical Research Innovation (CRI) Steering Committee is currently soliciting abstracts for the 11th Annual AACI CRI Meeting that will be held July 9-11 in Chicago. This year’s meeting theme…